Welcome to the topoSNP database. This site allows for the visualization of disease and non-disease associated non-synonymous single nucleotide polymorphisms (nsSNPs) and displays geometric and relative entropy calculations as described in Stitziel et. al. (JMB,327(5):1021-1030).

Please note you will need MDL's Chime Plugin to view this page correctly. It can be freely downloaded at http://www.mdlchime.com.

To start, please select one of the datasets to the right, or enter a protein sequence to BLAST search our database.

For help, see the help page.

This work is supported by grants from National Science Foundation (CAREER DBI0133856, DBI0078270, and MCB998008) and National Institute of Health (GM68958).
PDB: